Switra, an Ayurvedic term for a skin disorder resembling vitiligo, is characterized by depigmented patches due to Tridosa imbalance affecting tissues like Rasa, Rakta, and Mamsa. Switra Chikitsa employs a holistic approach, integrating Shodhana (purification), Shamana (palliative), and Rasayana (rejuvenation) therapies, alongside external applications and lifestyle modifications to restore pigmentation and balance. This review evaluates the scope of Switra Chikitsa, highlighting its potential through case studies and pilot trials that demonstrate repigmentation with minimal side effects using formulations like Bakuchi and Somaraji Taila. However, significant research gaps exist, including the lack of large-scale randomized controlled trials, unclear mechanisms of action, and non-standardized protocols. Limited exploration of psychological impacts and long-term safety, particularly with heavy metal-based drugs, further restricts its integration with modern dermatology. Addressing these gaps through rigorous scientific investigation could validate Switra Chikitsa’s efficacy, offering a complementary or alternative treatment for vitiligo with fewer adverse effects.